New instruments are required to allocate the available resources to services which are not only effective but also beneficial to the patients. These instruments are needed to manage the huge amount of new information in medicine and to appraise its quality. Evidence-based medicine (EBM) provides these instruments to find the relevant literature, to appraise its quality and to merge it with the user's clinical experience. EBM is different from "conventionally best medicine (CMB)" of four levels; conditions of clinical action, teaching goals, medicine at the patient, and goals of continued medical education. We can increase our chances to benefit from medical progress if we use these new instruments.