Role of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptors in Vascular Development
Role of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptors in Vascular Development
Distinct cellular processes mediate blood-vessel formation during embryogenesis (Beck and D’Amore 1997; Carmeliet and Collen 1998a; Folkman and D’Amore 1996; Noden 1989; Risau 1997; Wilting and Christ 1996) (Fig. 1). Initially, mesodermal cells differentiate in situ into early haemangioblasts and form cellular aggregates (blood islands), in which the inner-cell population develops into haematopoietic precursors and the outer-cell population gives rise to the primitive endothelial cells. In vitro findings suggest that basic fibroblast growth factor (bFGF or FGF2) may participate in angioblast differentiation via induction of a cellular receptor for vascular endothelial growth factor (VEGF-A) (Flamme and Risau 1992).
- Katholieke Universiteit Leuven Belgium
- KU Leuven Belgium
Vascular Endothelial Growth Factor A, Lymphokines, Vascular Endothelial Growth Factors, Neovascularization, Physiologic, Receptor Protein-Tyrosine Kinases, Endothelial Growth Factors, Genetic Therapy, Pregnancy Proteins, Cell Hypoxia, Receptors, Vascular Endothelial Growth Factor, Animals, Humans, Receptors, Growth Factor, Endothelium, Vascular, Placenta Growth Factor
Vascular Endothelial Growth Factor A, Lymphokines, Vascular Endothelial Growth Factors, Neovascularization, Physiologic, Receptor Protein-Tyrosine Kinases, Endothelial Growth Factors, Genetic Therapy, Pregnancy Proteins, Cell Hypoxia, Receptors, Vascular Endothelial Growth Factor, Animals, Humans, Receptors, Growth Factor, Endothelium, Vascular, Placenta Growth Factor
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