Immune Responses to Japanese Encephalitis Virus
Immune Responses to Japanese Encephalitis Virus
Japanese encephalitis (JE) is an acute viral encephalitis transmitted by mosquitoes, mainly Culex tritaeniorhyncus infected with JE virus. The ratio of asymptomatic to symptomatic infection is estimated to be 100:1–1000:1 (Vaughn and Hoke 1992). However, once symptoms develop, JE is a serious viral encephalitis with a high mortality rate and high percentage of neuropsychiatric sequelae (Hoke 1992; Monath and Heinz 1996; see chapter by Solomon and Vaughn, this volume). Japanese data during the past 20 years demonstrated that the mortality rate was 17%, 48% of the patients recovered with neuropsychiatric sequalae, and only 31% recovered completely (Matsunaga et al. 1999).
Encephalitis Virus, Japanese, Flavivirus, Viral Vaccines, Antibodies, Viral, Mice, Viral Proteins, Neutralization Tests, Animals, Humans, Encephalitis, Japanese, T-Lymphocytes, Cytotoxic
Encephalitis Virus, Japanese, Flavivirus, Viral Vaccines, Antibodies, Viral, Mice, Viral Proteins, Neutralization Tests, Animals, Humans, Encephalitis, Japanese, T-Lymphocytes, Cytotoxic
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