Most people require diagnostic tests during their lifetime in order to detect a suspected malignancy, plan a therapy and follow-up on a treatment. In almost all of these cases diagnostic tests entail a single imaging examination or a series of complementary imaging exams. Non-invasive imaging is central to personalized disease management and includes imaging technologies such as Computed Tomography (CT), Single Photon Emission Computed Tomography (SPECT), Magnetic Resonance Imaging (MRI), Ultrasound (US) or Positron Emission Tomography (PET).