Low complication rates of transcatheter ASD closure and robust long-term results have led to a high acceptance of this method by physicians and patients alike. Consequently, this interventional technique has led to the replacement of surgery as the standard therapeutic approach. All septal occluders available today are relatively easy to use by experienced operators and are available in different sizes to accommodate the highly variable ASD morphology and sizes. Careful patient selection and knowledge of specific implantation strategies for complex defects allow experienced operators to consider transcatheter ASD closure even in challenging cases.