Muscarinic Receptor Antagonists: Effects on Pulmonary Function

In healthy lungs, muscarinic receptors control smooth muscle tone, mucus secretion, vasodilation, and inflammation. In chronic obstructive pulmonary disease (COPD) and asthma, cholinergic mechanisms contribute to increased bronchoconstriction and mucus secretion that limit airflow. This chapter reviews neuronal and nonneuronal sources of acetylcholine in the lung and the expression and role of M₁, M₂, and M₃ muscarinic receptor subtypes in lung physiology. It also discusses the evidence for and against the role of parasympathetic nerves in asthma, and the current use and therapeutic potential of muscarinic receptor antagonists in COPD and asthma.

Related Organizations

Oregon Health & Science University
United States

Keywords

Muscarinic Antagonists, Receptors, Muscarinic, Acetylcholine, Asthma, Bronchodilator Agents, Pulmonary Disease, Chronic Obstructive, Parasympathetic Nervous System, Animals, Humans, Lung, Signal Transduction

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