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Neural Stem Cells

Name: Neural Stem Cells
Creator: Maija L. Castrén
Keywords: 0301 basic medicine, Mice, Knockout, 0303 health sciences, Cell Culture Techniques, 3. Good health, 03 medical and health sciences, Disease Models, Animal, Fragile X Mental Retardation Protein, Mice, Neural Stem Cells

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 21 Sep 2011Publisher:Springer Berlin Heidelberg

Authors: Maija L. Castrén;

doi: 10.1007/978-3-642-21649-7_3

pmid: 22009346

Neural Stem Cells

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Abstract

Neural stem/progenitor cell (NPC) cultures are a tool to study the differentiation of neuronal cells and can be used to model disease conditions in studies investigating the pathological mechanisms affecting the development and cellular plasticity of the central nervous system. There is evidence that abnormalities of NPCs and their differentiation contribute to the pathophysiology of fragile X syndrome. The results obtained with NPC cultures derived from human and mouse brain tissue with the fragile X mutation are in line with the abnormalities of Fmr1-knockout mouse brain in vivo indicating that NPC cultures can be useful as a model for fragile X syndrome.

Related Organizations

University of Helsinki
Finland

Keywords

Mice, Knockout, Cell Culture Techniques, Disease Models, Animal, Fragile X Mental Retardation Protein, Mice, Neural Stem Cells, Fragile X Syndrome, Animals, Humans, Cells, Cultured

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	4
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average