With the recent advance of biomedical technology, a lot of ‘OMIC’ data from genomic, transcriptomic, and proteomic domain can now be collected quickly and cheaply. One such technology is the microarray technology which allows researchers to gather information on expressions of thousands of genes all at the same time. With the large amount of data, a new problem surfaces – how to extract useful information from them. Data mining and machine learning techniques have been applied in many computer applications for some time. It would be natural to use some of these techniques to assist in drawing inference from the volume of information gathered through microarray experiments. This chapter is a survey of common classification techniques and related methods to increase their accuracies for microarray analysis based on data mining methodology. Publicly available datasets are used to evaluate their performance.