It is not acceptable to work with patients with dangerous infections without using, knowing and implementing adequate personal protective equipment—PPE. Personnel, patients and visitors should not be exposed to infectious agents by patients, others, equipment or the environment—which may be serious to health or life (ECDC). It is not acceptable to place a patient with undefined infectious disease in the same room as a patient with known high-risk disease (WHO). In this chapter the need and use of PPE are described, to stop spread of infections in the hospital during outbreaks.