Diagnostic imaging and in particular cross-sectional modalities (US, CT, and MR) have a critical and complementary role in diagnosis and management of small bowel diseases. Radiologists should be aware of advantages and disadvantages of each imaging test in order to choose the best option, considering the specific small bowel disease and the patient’s characteristics (age, gender, clinical status). US is a powerful tool, especially in combination with oral (SICUS) and intravenous (CEUS) contrast agents. CT is the imaging modality of choice in the emergency setting (i.e., small bowel occlusion, ischemia, and, in some circumstances, bleeding). MR is the preferred imaging test in benign disorders, and in particular inflammatory bowel diseases (IBDs), because of multiparametric approach, evaluation of bowel motility, and lack of radiation exposure. A brief review of main findings in different pathological entities involving the small bowel is provided, in order to offer to radiologists the instruments for a correct diagnosis and for providing the clinicians with the necessary information for patient management.