In this chapter, healthcare today is characterized by innovation and organizational change. The implementation of innovations is mainly directed toward improvement of quality, patient safety, or patient satisfaction, taking the financial and human resources of healthcare organizations into consideration. Healthcare systems have to change their focus from cost-efficiency to a more value-based approach. In this approach, value for patients is calculated by dividing cost by quality. To increase value for patients, we have to implement innovations that improve the quality and reduce the costs of services. This chapter explores how two specific strategies, project management (PM) and plan-do-study-act (PDSA) or plan-do-check-act (PDCA) cycles, can promote the implementation of innovations and thus improve the value of care.