It is known that high levels of cholesterol, triglycerides, and low-density lipoprotein (LDL) may determine vessel wall damage. As it is also known that tendon tissue insertion to the greater tuberosity of the humerus normally receives a poor blood supply, especially with the arm in adducted position [1], some authors have hypothesized that hypercholesterolemia may be an additional risk factor for tissue degeneration and, consequently, for rotator cuff tear.