The superior vena cava syndrome (SVCS) refers to a group of symptoms caused by obstruction or compression of the superior vena cava. Malignant causes represents the majority of all cases of SVCS (bronchogenic carcinoma, lymphoma, metastatic breast carcinoma, primary mediastinal tumors, acute leukemias). SVCS may be due to iatrogenic causes such as presence of intravascular devices (e.g., permanent central venous access catheters, pacemaker/defibrillator leads). Syphilis and tuberculosis have also been known to cause SVCS.