Childhood constipation is a common and worldwide pediatric healthcare problem. The diagnosis is based on history and physical examination, in accordance with the pediatric diagnostic Rome IV criteria. Diagnostic tests are only indicated if the diagnosis is not clear or in order to rule out an underlying organic disease. Non-pharmacological management involves education, demystification, a toilet program with reward system, and daily bowel diary, and in some cases additional cognitive behavior therapy is helpful. Pharmacological treatment with laxatives consists of disimpaction, maintenance treatment, and weaning from medication. Polyethylene glycol (PEG) is the treatment of first choice for both disimpaction and maintenance treatment. If PEG is not available or poorly tolerated, other laxatives are available as second-line or additional treatment if treatment with PEG is insufficient. In children with more severe symptoms not improving with the previously listed interventions, pelvic floor physiotherapy, sacral nerve stimulation, and surgery can be considered.