This chapter aims to be the “appetizer” for all those who approach plastic surgery. Indeed, it is without question that surgeons must have detailed knowledge of the surgical principles, as well as surgical anatomy, of the areas in which they will be operating. This chapter includes the basics of tissue handling and surgical instruments. All the efforts that must be made to avoid microorganisms from entering the incision (asepsis) and to eliminate microorganisms if they have already entered (antisepsis), for example, sterile gowns, gloves, and masks, are illustrated. In addition, the chapter will focus on offering an overview of commonly used wound closure materials as well as wound closure techniques and special suture techniques. The primary objective of suturing is to position and secure surgical flaps to promote optimal healing. Suturing reduces postoperative pain and increases patient comfort. It reduces the chances of infection. The basic terminology and characteristics of needles and sutures, skin staples, closure tapes, and skin adhesives are presented as the selection of appropriate suturing technique and the type and diameter of the surgical needle is of paramount importance.