Scarring alopecia, also referred to as cicactricial alopecia, is characterized by an irreversible inflammatory destruction of hair follicles, which are replaced with scar tissue and hair loss patches. Scarring alopecia can have a significant psychological and emotional stress on patients due to its poor prognosis and common failure of current treatments compared to non-scarring alopecia (Katoulis et al., J Dtsch Dermatol Ges. 13;137–42, 2015). Recently, platelet-rich plasma (PRP) has emerged as a promising therapy for treating hair loss disorders. Although there is growing body of evidence showing the efficacy and safety of PRP in non-scarring alopecia, such as androgenetic alopecia (AGA) and alopecia areata (AA), there is scarce evidence on the clinical benefits of PRP in scarring alopecia (Juhasz et al., J Drugs Dermatol. 19(7):736–41, 2020; Dubin et al., J Am Acad Dermatol. 83(5):1294–97, 2020; Shapiro et al., J Am Acad Dermatol. 83(5):1298–303, 2020). In this chapter, we explore how PRP may be effective in treating scarring alopecia and summarize the evidence from the literature and the authors.