Photophobia is one of the most common visual complaints stemming from mild traumatic brain injury (mTBI) and causes significant distress. Despite extensive research, the etiology of photophobia is poorly understood, and symptoms are difficult to treat. No randomized controlled trials of treatment of photophobia in patients with mTBI exist; however, tinted glasses have been tried with some success. Targeted therapies involving infusion of calcium gene-related peptide antibody may hold promise.