Retirement represents one of the greatest life milestones one can experience. It was conjured by humans to allow those who worked an opportunity to receive a well-deserved break and to enjoy life without employment obligations. There are certainly similarities and differences when comparing the process of retirement between people and therapy animals. Working therapy animals deserve the opportunity to retire with dignity. The primary goal of this chapter is to provide guidelines to consider for the safe retirement of therapy animals as well as highlight the implications of this retirement on the handlers as well as the clients. Attention in the chapter is also given to the leadership of the various organizations registering therapy animals to assure that a mechanism is in place to monitor the lifespan of therapy animals so they can be given the opportunity to transition into retirement years.