There has been tremendous advancements and innovations in the field of material science, technology and adhesive dentistry which has brought about a sea of change in the way we practice dentistry today. Transformations from the traditional dentistry to digital dentistry is making far-reaching consequences to patient care and also affecting the landscape of digitization of restorative dentistry (Kaye. Dent Today. 35:22–27, 2016). The CAD/CAM, introduced in 1973, was further developed and introduced in 1987 as CEREC (Sirona dental systems), as the first commercially available CAD/CAM system for dental restorations (Logozzo S et al., Internet J Med Technol 2008;5(1)). The chapter will give a brief introduction about caries detection methods and then guide through the digital processing of a ceramic inlay talking about all the steps from tooth preparation, digital impression taking, data processing and manufacturing/milling to try in and cementation. Subtraction and additive methods of digital manufacturing will also be discussed at the end of the chapter in brief.