Total-body ultraviolet therapy (UV) for moderate-to-severe psoriasis consists of narrowband and broadband-UVB, psoralen plus UVA (PUVA—where psoralen can be ingested orally or applied topically), inpatient phototherapy (i.e. Goeckerman Therapy, Ingram therapy), non-office-based phototherapy (i.e. use of commercial sunlamps/sunbeds or home UVB for psoriasis treatment, heliotherapy, climatotherapy), and combined UVB/PUVA with retinoid or biologic agents. For each type of UV therapy discussed in this chapter, essential information regarding dosage and administration, efficacy (including comparator data if available), short-term side effects, and long-term photocarcinogenic risks are discussed. A well-balanced understanding of the advantages and drawbacks of each photo-therapeutic option can help phototherapy practitioners optimize clinical outcomes as well as enhance the quality of life for patients affected by this chronic skin condition.