Although many types of radionuclide studies are similar in adults and children, there is specific consideration to be aware of in the pediatric population. Careful planning and good communication is essential for acquiring an optimum study. Having the appropriate tools, environment, and enough time is of pivotal importance. In addition, it is important to be aware of the normal variances and appropriate thresholds in order to interpret an activity as abnormal in children as compared with adults. In this chapter we review the common nuclear medicine procedures in children, focusing on the indication of the study, patient preparation, dose of the radioactivity, and the interpretation of the studies. Furthermore, common pediatric protocols are also summarized for the quick review. We hope this chapter is useful for learning the practical information nuclear medicine physicians or radiologists need to know for pediatric cases.