Infectious diseases of the liver include pyogenic and amebic abscesses and viral, fungal, parasitic and granulomatous infections. Imaging plays a fundamental role in diagnosis and follow-up of infectious liver diseases. All imaging modalities including ultrasonography, computed tomography, and magnetic resonance imaging may be helpful for detection and characterization of most hepatic infections. In certain patients, imaging may provide very specific signs to characterize the pathogen and confidently exclude other non-infectious clinical entities with similar imaging features.