Despite the continued refinement of vascular ultrasound and noninvasive cross-sectional imaging studies (computed tomography angiography [CTA] and magnetic resonance angiography [MRA]) in the diagnosis of vascular pathologies, digital subtraction angiography (DSA) remains the “workhorse” imaging modality for the diagnosis and management of peripheral arterial disease. Despite its inherent invasiveness, catheter-based DSA provides excellent spatial resolution of vascular pathology in a time-resolved fashion, allowing for detailed anatomic assessments and direct visualization of “flow” within a given vessel. The ability of DSA studies to capture high-resolution anatomic and physiologic information within relatively large two-dimensional anatomic fields of view (FOV) provides the basis for DSA being considered the “gold standard” diagnostic imaging modality for many vascular pathologies.