Multidetector CTA (MDCTA) of the peripheral arteries has high accuracy for detection of steno-occlusive diseases when compared with DSA. Its advantages over DSA include minimal invasiveness, reduced volume of contrast material, shorter scan times, and fast data acquisition. Other advantages include three-dimensional (3D) volumetric data analysis and display, unlike DSA which only provides a luminogram, visualization of the vessel walls, and extravascular tissues. Furthermore CTA is more reliable than MRA when assessing patency of arteries with stents and has higher spatial resolution. This chapter reviews the role of CTA for the evaluation and posttreatment follow-up of patients with PAD involving the upper and lower extremities.