The advent of stereotactic and ultrasound (US) guidance combined with the development of automatic, easy-to-use core-needle biopsy (CNB) devices marked the beginning of a new era in the field of imaging-guided percutaneous breast biopsy. The various automatic and manual devices available for CNB and their mechanisms are described. The complete standard technique of the CNB procedure is detailed from the preparation of the patient to the processing of the cores. A large section is devoted to the documentation of the procedure. Artifacts, errors, and pitfalls in the performance of US-guided CNB are discussed along with their solutions. Finally, an original technique of US-guided CNB of the skin is presented.