The indications for minimally invasive spine surgery (MISS) for the treatment of thoracic disc disease have evolved and expanded over the past decade with the development of newer technologies and refined techniques. Symptomatic thoracic disc herniations are uncommon, which provides a paucity of literature exploring common surgical treatment options. The clinical presentation is highly variable, and the diagnosis is often delayed. The most common indications for thoracic discectomy include spinal cord compression with myelopathy or refractory radiculopathy.