Migraine is the most prevalent neurological disorder worldwide; nevertheless, its pathophysiology is not yet completely understood. Recent scientific progresses in migraine research disclosed new possible targets for novel non-pharmacological treatment strategies for migraine treatment, such as noninvasive neuromodulation methods. Among them, transcranial direct current stimulation (tDCS) gave promising results in pilot studies. tDCS is a noninvasive, safe, and relatively not expensive technique of cortical electrical stimulation, aimed to modulate cortical activity in many ways, according to the stimulated sites and the polarity used. Unfortunately, large sham-controlled trials are not yet available to confirm its potential use as a preventative treatment for migraine.