Right ventricular (RV) size and function have been found to be important predictors of cardiovascular morbidity and mortality in patients with various clinical conditions. However, assessment of the RV using conventional two-dimensional echocardiography is a challenging task due to the complex anatomy and the location of the RV in the chest. Although cardiac magnetic resonance is considered a “gold standard” for RV assessment, the development of three-dimensional echocardiography (3DE) opened new exciting opportunities in RV imaging. 3DE has proven accurate in measuring RV volumes and ejection fraction when compared with cardiac magnetic resonance. During the last decade, the added prognostic value of using 3DE to assess RV geometry and function over conventional two-dimensional and Doppler echocardiography has been increasingly reported.