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High-Throughput Methods for SNP Genotyping

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 2009Publisher:Humana Press

Authors: Shengnan Jin; Chunming Ding;

doi: 10.1007/978-1-60327-411-1_16

pmid: 19768599

High-Throughput Methods for SNP Genotyping

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Abstract

Single nucleotide polymorphisms (SNPs) are ideal markers for identifying genes associated with complex diseases for two main reasons. Firstly, SNPs are densely located on the human genome at about one SNP per approximately 500-1,000 base pairs. Secondly, a large number of commercial platforms are available for semiautomated or fully automated SNP genotyping. These SNP genotyping platforms serve different purposes since they differ in SNP selection, reaction chemistry, signal detection, throughput, cost, and assay flexibility. This chapter aims to give an overview of some of these platforms by explaining the technologies behind each platform and identifying the best application scenarios for each platform through cross-comparison. The readers may delve into more technical details in the following chapters.

Related Organizations

Chinese University of Hong Kong
China (People's Republic of)
Prince of Wales Hospital
China (People's Republic of)
Hospital Authority
China (People's Republic of)

Keywords

Genotype, Humans, Physical Chromosome Mapping, Polymorphism, Single Nucleotide, Genome-Wide Association Study, High-Throughput Screening Assays

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
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