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Delivering Small Interfering RNA for Novel Therapeutics

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article , Other literature type 01 Jan 2008Publisher:Humana Press

Authors: Patrick Y. Lu; Martin C. Woodle;

doi: 10.1007/978-1-59745-210-6_3

pmid: 18369963

pmc: PMC7122746

Delivering Small Interfering RNA for Novel Therapeutics

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Abstract

The gene silencing capability of RNA interference (RNAi) is being used to study individual gene's biological function and role in biochemical pathways. However, the efficacy of RNAi depends upon efficient delivery of the intermediates of RNAi, small interfering RNA (siRNA) oligonucleotides. The delivery challenge is even greater when the aim is to inhibit the expression of target genes in disease tissues. In vivo delivery of siRNA is complicated and challenging, and recent works on various animal disease models and early successes in human clinical trials are enlightening the tremendous potential of RNAi therapeutics. In this chapter, the latest developments of in vivo delivery of siRNA and the critical issues related to this effort are addressed.

Keywords

Drug Delivery Systems, Animals, Humans, RNA, Small Interfering, Article

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	22
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	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%