Multilectin receptors, as the name implies, have multiple lectin domains present within a single peptide backbone. There are four known members in this class of molecules, the best studied of which is the macrophage mannose receptor (MR). This chapter discusses the structure and function of the multilectin receptors as represented by the macrophage MR and its proposed role in the innate immune response (for recent review articles on the mannose receptor, see refs. 1–3).