Protein Structure Modeling with MODELLER
Protein Structure Modeling with MODELLER
Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized at atomic resolution using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. In the following chapter, we present an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of a similar protocol has resulted in models of useful accuracy for domains in more than half of all known protein sequences.
- University of California System United States
- University of California, San Francisco United States
- QB3 United States
Models, Molecular, 570, Protein Conformation, Fold assignment, Bioinformatics and Computational Biology, Model assessment, Databases, Models, Medicinal and biomolecular chemistry, Amino Acid Sequence, Databases, Protein, Sequence-structure alignment, Internet, Protein, Multiple templates, 500, Molecular, Proteins, Biological Sciences, Comparative modeling, Biochemistry and cell biology, Biochemistry and Cell Biology, Generic health relevance, Other Chemical Sciences, Software, Developmental Biology
Models, Molecular, 570, Protein Conformation, Fold assignment, Bioinformatics and Computational Biology, Model assessment, Databases, Models, Medicinal and biomolecular chemistry, Amino Acid Sequence, Databases, Protein, Sequence-structure alignment, Internet, Protein, Multiple templates, 500, Molecular, Proteins, Biological Sciences, Comparative modeling, Biochemistry and cell biology, Biochemistry and Cell Biology, Generic health relevance, Other Chemical Sciences, Software, Developmental Biology
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