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Genome Editing of Monkey

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 2017Publisher:Springer New York

Authors: Zhen Liu; Qiang Sun; Yijun Cai;

doi: 10.1007/978-1-4939-7128-2_12

pmid: 28643256

Genome Editing of Monkey

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Abstract

Gene-modified monkey models would be particularly valuable in biomedical and neuroscience research. Virus-based transgenic and programmable nucleases-based site-specific gene editing methods (TALEN, CRISPR-cas9) enable the generation of gene-modified monkeys with gain or loss of function of specific genes. Here, we describe the generation of transgenic and knock-out (KO) monkeys with high efficiency by lentivirus and programmable nucleases.

Related Organizations

Chinese Academy of Sciences
China (People's Republic of)
Shanghai Institutes for Biological Sciences
China (People's Republic of)
Center for Excellence in Brain Science and Intelligence Technology
China (People's Republic of)

Keywords

Animals, Genetically Modified, Gene Editing, Gene Knockout Techniques, Animals, Female, Haplorhini, Sperm Injections, Intracytoplasmic, CRISPR-Cas Systems, Endonucleases

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	2
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average