Long-term potentiation (LTP) is a strengthening of synaptic transmission that was first discovered in the hippocampus (Bliss and Lomo, 1973). If one stimulates the afferents to the hippocampus at a high rate (100 Hz for 3 sec), the excitatory postsynaptic potentials in the hippocampal pyramidal cells are subsequently found to be larger than normal, and to rise more quickly. The effect lasts for several hours, and can last for as long as the preparation does.

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Yale University
United States

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