At a dinner speech in Atlantic City in 1950, Otto Loewi commented on some facets of his work that had led to the discovery of neurochemical transmission. He mentioned that Sir Walter Fletcher, years after the discovery, reminded him that as far back as 1903 Loewi had pointed out to him the possibility of a neurochemical transmission. As we know, this idea gradually developed, and the ripe fruit fell into Loewi’s hands in 1921 after a series of genially simple experiments. At the 1926 International Physiological Congress in Stockholm, Loewi demonstrated his experiments, which were to revolutionize the concepts of nerve transmission. As a medical student I had the opportunity to be present and also to make the personal acquaintance of this great scientist and charming and witty man.