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Purine Nucleotide Restoration in HPRT- Cells

Name: Purine Nucleotide Restoration in HPRT- Cells
Creator: Theodore Page
Keywords: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Hypoxanthine Phosphoribosyltransferase, Lesch-Nyhan Syndrome, Humans, Fibroblasts, Purine Nucleotides, Cells, Cultured, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 1989Publisher:Springer US

Authors: Theodore Page;

doi: 10.1007/978-1-4684-5673-8_30

pmid: 2624188

Purine Nucleotide Restoration in HPRT- Cells

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Abstract

Lesch-Nyhan syndrome is caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) (1, 2). This enzyme catalyzes the conversion of the purine bases hypoxanthine and guanine to their respective 5′ribo-nucleotides. It is reasonable to assume that a deficiency of HPRT would cause a decrease in the cellular concentrations of purine nucleotides, although such a decrease has not been demonstrated in nucleated HPRT cells.

Related Organizations

University of California, San Diego
United States

Keywords

Hypoxanthine Phosphoribosyltransferase, Lesch-Nyhan Syndrome, Humans, Fibroblasts, Purine Nucleotides, Cells, Cultured

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