Evolution of Conformational Flexibility of Immunoglobulin M
Evolution of Conformational Flexibility of Immunoglobulin M
Since the initial observations of Heidelberger and Pederson (1) of a macroglobulin antibody against pneumococcus in the horse, IgM has been recognized as a major class of immunoglobulins in mammals as well as in vertebrates as phylogenetically distant as the elasmobranchii (2). In fact, IgM appears to be the first recognizable class to have evolved. It still is the first immunoglobulin to be synthesized in a mammalian immune response.
- Tufts University United States
Protein Conformation, Swine, Biological Evolution, Immunoglobulin Fc Fragments, Immunoglobulin Fab Fragments, Immunoglobulin M, Antibody Specificity, Sharks, Animals, Binding Sites, Antibody, Horses, Mathematics
Protein Conformation, Swine, Biological Evolution, Immunoglobulin Fc Fragments, Immunoglobulin Fab Fragments, Immunoglobulin M, Antibody Specificity, Sharks, Animals, Binding Sites, Antibody, Horses, Mathematics
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