By far the majority of studies with cytokines relate to neuroendocrine functions, fever and sleep.1 Recently, however, the possibility of a role for cytokines in nociception has been explored. In particular the work of Watkins et al2,3 have studied central and peripheral involvement of IL-1β in nociception in depth. This chapter will attempt to review the literature relating to those cytokines (primarily IL-1β, IL-2, IL-6, TNF-α and NGF) for which there is some direct evidence for a role in nociception.

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	2
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average