Name: Heparin Cofactor II
Creator: D M, Tollefsen
Keywords: 0301 basic medicine, Mammals, Models, Molecular, 0303 health sciences, 03 medical and health sciences, Binding Sites, Protein Conformation, Heparin Cofactor II, Animals, Humans

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 1997Publisher:Springer US

Authors: D M, Tollefsen;

doi: 10.1007/978-1-4615-5391-5_4

pmid: 9433487

Heparin Cofactor II

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Abstract

Heparin cofactor II (HCII) is a serpin that inhibits thrombin rapidly in the presence of dermatan sulfate or heparin. Both of these glycosaminoglycans bind to HCII and increase the rate of inhibition of thrombin >1000-fold. This review will focus on the biochemistry of HCII and the mechanism by which glycosaminoglycans stimulate its activity.

Related Organizations

University of Mary
United States
Washington University in St. Louis
United States

Keywords

Mammals, Models, Molecular, Binding Sites, Protein Conformation, Heparin Cofactor II, Animals, Humans, Amino Acid Sequence, Glycosaminoglycans

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