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Part of book or chapter of book . 1993 . Peer-reviewed

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Pharmacokinetics of Desmopressin

Name: Pharmacokinetics of Desmopressin
Keywords: 3. Good health

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 01 Jan 1993 English Publisher:Springer US

Authors: M. Köhler; Harris Alan;

doi: 10.1007/978-1-4615-2922-4_7

Pharmacokinetics of Desmopressin

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Abstract

In 1967 Zaoral and coworkers synthesized several analogues of vasopressin. One of these derivatives, 1-deamino-8-D-arginine vasopressin (DDAVP, desmopressin), soon became the treatment of choice for diabetes insipidus centralis. DDAVP has a prolonged half-life and a decreased pressor activity when compared with the parent hormone vasopressin (VP). This allows the use of significantly higher dosages without the cardiovascular side effects of VP. Gader et al. (1973), Cash (1974) and Mannucci (1977) observed that DDAVP increases Factor VIII (FVIII) and von Willebrand Factor (vVF) in healthy subjects and patients with bleeding disorders such as milder forms of haemophilia A and von Willebrand’s disease.In these disorders, desmopressin proved not only to be a substitute for blood products, but also the most effective treatment.

Related Organizations

University of Göttingen
Germany
Ferring Pharmaceuticals (Switzerland)
Switzerland

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