Because emotional exhaustion is the key component of burnout, it is important to recognize the factors that may promote emotional exhaustion. According to recent studies, psychosocial work factors are likely to generate emotional exhaustion among employees. The central aim of this chapter is to analyze the associations between emotional exhaustion and psychosocial work factors among middle-aged employees. This chapter includes some ideas on what kind of studies and information are required on this issue in the future, as well as some guidelines on how to prevent emotional exhaustion in the workplace and improve employees’ health and well-being.