Genome-Wide Occupancy Analysis by ChIP-chip and ChIP-Seq
Genome-Wide Occupancy Analysis by ChIP-chip and ChIP-Seq
Interaction between protein complexes and the genome mediates essential functions including gene regulation, genome integrity, and chromatin organization. Recent advances in chromatin immunoprecipitaion (ChIP)-chip and ChIP-Seq technologies have enabled genome-wide identification of occupancy of transcription factors and modified histones that is critical for uncovering gene regulatory networks. This review discusses ChIP-chip and ChIP-Seq technology, their pitfalls, insights from genome-wide occupancy studies, and applications pertaining to vertebrate retina.
- National Institute of Health Pakistan
- National Eye Institute United States
- National Institutes of Health United States
Gene Expression Regulation, Animals, Humans, Gene Regulatory Networks, Genome-Wide Association Study, Oligonucleotide Array Sequence Analysis, Transcription Factors
Gene Expression Regulation, Animals, Humans, Gene Regulatory Networks, Genome-Wide Association Study, Oligonucleotide Array Sequence Analysis, Transcription Factors
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Citations provided by BIP!Popularity provided by BIP!