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Antibodies to von Willebrand factor in von Willebrand disease

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 1995 English Publisher:Springer US

Authors: Pier Mannuccio Mannucci; Augusto B. Federici;

doi: 10.1007/978-1-4613-0331-2_7

pmid: 8851017

Antibodies to von Willebrand factor in von Willebrand disease

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Abstract

The occurrence of an alloantibody directed against von Willebrand factor in a multitransfused patient with severe (type III) von Willebrand disease was first reported in 2 consecutive studies by Sarji et al. (1974) and Stratton et al. (1975). After this, 14 additional cases of alloantibodies were described and reviewed by Mannucci and Mari (1984). A survey carried out on behalf of the World Federation of Hemophilia identified 6 additional cases that, added to the 15 cases previously reported, bring to 21 the total number of patients reported so far with anti-von Willebrand factor alloantibodies (Mannucci and Cattaneo, 1991). In the frame of the survey, Hanna (1989) reported an antibody directed towards factor VIII (F.VIII) in a girl with severe von Willebrand disease. Since this antibody did not apparently react with von Willebrand factor, it will not be reviewed here.

Related Organizations

University of Milan
Italy

Keywords

Adult, Male, Adolescent, Infant, Middle Aged, von Willebrand Diseases, Isoantibodies, Child, Preschool, von Willebrand Factor, Humans, Female, Child, Aged

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	60
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average