Cutaneous squamous cell carcinoma (SCC) is the most common skin cancer in much of the world (1). Although it can occur in any anatomic location on the body, it tends to develop from a predisposing cutaneous dysplasia rather than de novo. The overwhelming majority of cutaneous squamous cell carcinomas develop within solar (actinic) keratoses and rarely are aggressive. However, de novo lesions and those that develop from scar keratoses, chronic radiation keratoses, tar keratoses, thermal keratoses, or on mucosal surfaces have a greater malignant potential (1, 2).