Despite its unequivocal benefits to humankind, vaccine design and development has always been an inherently laborious and a largely empirical process; the unfortunate lack of a rational basis for vaccinology has hitherto stymied the commercial exploitation of vaccine discovery and also the deployment of vaccination as the principal, global instrument of public health provision. Immunoinformatics offers a plethora of programs and techniques that have the potential to simplify greatly the process of discovering vaccines. These techniques can assist in the identification of immunogenic epitopes that might be overlooked by conventional experimentation.