Titan's atmosphere is predominantly N2 with CH4 the next most abundant molecule. It has a mole fraction of 0.05 just above the surface decreasing to 0.014 in the stratosphere. Above the homopause (~800–850 km), it increases to 0.12 at the exobase. The third abundant molecule is H2 with a tropospheric mole fraction of 0.001 increasing to 0.004 at ~1000 km and ~0.02 at the exobase (~1500– 1600 km). This chapter reviews the various measurements acquired by the Voyager flybys, Huygens Probe, orbiting Cassini spacecraft, ground-based and orbiting telescopes of the large suite of hydrocarbons, nitriles, other nitrogen and also oxygen bearing compounds. Titan possesses a mostly stable troposphere with a well defined tropopause (T ~ 70 K at ~44 km) and a lower stratosphere with a high static stability, which is extremely cold over the winter polar region (currently northern hemisphere) and warm over the summer pole. Remarkably in the middle stratosphere, the warmest temperatures occur at the equator and the largest meridional temperature gradients are found in the winter hemisphere. The stratopause from the summer pole to about 45° N remains at a relatively constant pressure of 0.1 mbar/300 km and then it rises rapidly upward to ~0.01 mbar/400 km at the winter north pole, where it is the warmest region in the entire atmosphere. One possible interpretation of the Huygens Atmospheric Structure Instrument (HASI) temperature profile is that Titan's atmosphere is essentially isothermal ~170 K from 500–1100 km, with large amplitude thermal waves (10 K) superimposed. The existence and location of a well defined mesopause is an open question.