Reverse Genetics Systems for Filoviruses

Filoviruses are causative agents of severe hemorrhagic fevers with high case fatality rates in humans. For studies of virus biology and the subsequent development of countermeasures, reverse genetic systems, and especially those facilitating the generation of recombinant filoviruses, are indispensable. Here, we describe the generation of recombinant filoviruses from cDNA.

Related Organizations

Friedrich Loeffler Institute
Germany

Keywords

DNA, Complementary, Humans, Hemorrhagic Fever, Ebola, Filoviridae, Ebolavirus, Reverse Genetics

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