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Computational Analysis of Antibody Paratopes for Antibody Sequences in Antibody Libraries

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 09 Nov 2022 English Publisher:Springer US

Authors: Hung-Pin, Peng; An-Suei, Yang;

doi: 10.1007/978-1-0716-2609-2_24

pmid: 36346607

Computational Analysis of Antibody Paratopes for Antibody Sequences in Antibody Libraries

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Abstract

To ensure the functionalities of the antibodies in phage-displayed synthetic antibody libraries, we use computational method to evaluate the designs of the antibody libraries. The computational methodologies developed in our lab for designing antibody library provide rich information on the function of the designed antibody sequences-adequate antibody designs for a specific antigen type should have predicted paratopes for the antigen type. This computational assessment of the designed antibody sequences helps eliminate non-functional designs before proceeding to construct the library designs in the wet lab. As such, only reasonable antibody designs are constructed for antibody discoveries.

Related Organizations

Academia Sinica
Taiwan

Keywords

Peptide Library, Binding Sites, Antibody, Antigens, Antibodies

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