Mathematical Modeling of ceRNA-Based Interactions
Mathematical Modeling of ceRNA-Based Interactions
Competing endogenous RNA (ceRNA) molecules have emerged as key players in regulating gene expression, increasing the complexity of the range of possible dynamics within a cell. The actions of competing RNA typically are sponging behaviors, in a manner that fine-tunes gene expression, but there are particular network structures that may show destabilization due to ceRNA interactions. In this chapter, we discuss how these interactions can be modeled and probed from a mathematical, first-principles perspective.
- Cleveland Clinic United States
- The Neurological Institute United States
RNA, Untranslated, Computational Biology, Models, Theoretical, Regulatory Sequences, Ribonucleic Acid, MicroRNAs, Gene Expression Regulation, Gene Regulatory Networks, RNA, Long Noncoding, RNA, Messenger, Algorithms, Pseudogenes
RNA, Untranslated, Computational Biology, Models, Theoretical, Regulatory Sequences, Ribonucleic Acid, MicroRNAs, Gene Expression Regulation, Gene Regulatory Networks, RNA, Long Noncoding, RNA, Messenger, Algorithms, Pseudogenes
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