Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)
Measurement of the Intracellular Mycobacterium tuberculosis Drug Effect and Prediction of the Clinical Dose–Response Relationship Using Intracellular Pharmacodynamic Modeling (PDi)
The human disease tuberculosis (TB) is the leading cause of death from a single infectious agent. A quarter of the world's population is estimated to be latently infected. Drug development and screening is slow and costly. We have developed a physiologically relevant assay to screen drugs against TB when inside immune cells. This chapter will describe a newly developed preclinical drug screening assay for TB, using high-content imaging and pharmacokinetic/pharmacodynamic modeling.
- Liverpool School of Tropical Medicine United Kingdom
- University of Liverpool United Kingdom
Bacterial Proteins, Dose-Response Relationship, Drug, Drug Development, THP-1 Cells, Antitubercular Agents, Humans, Tuberculosis, Mycobacterium tuberculosis
Bacterial Proteins, Dose-Response Relationship, Drug, Drug Development, THP-1 Cells, Antitubercular Agents, Humans, Tuberculosis, Mycobacterium tuberculosis
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